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Literature summary extracted from

  • Cho, K.; Tanaka, T.; Cook, R.R.; Kisiel, W.; Fujikawa, K.; Kurachi, K.
    Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates (1984), Biochemistry, 23, 644-650.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.21.38 0.006
-
 benzyloxycarbonyl-Phe-Arg-SCH2CH(CH3)2
-
 Homo sapiens
3.4.21.38 0.012
-
 benzyloxycarbonyl-Ala-Arg-SCH2C6H5
-
 Homo sapiens
3.4.21.38 0.019
-
 benzyloxycarbonyl-Met-Arg-SCH2CH(CH3)2
-
 Homo sapiens
3.4.21.38 0.034
-
 benzyloxycarbonyl-Ala-Arg-SCH2CH(CH3)2
-
 Homo sapiens
3.4.21.38 0.036
-
 benzyloxycarbonyl-Gly-Arg-SCH2CH(CH3)2
-
 Homo sapiens
3.4.21.38 0.036
-
 benzyloxycarbonyl-Pro-Arg-SCH2CH(CH3)2
-
 Homo sapiens
3.4.21.38 0.046
-
 benzyloxycarbonyl-Val-Arg-SCH2CH(CH3)2
-
 Homo sapiens
3.4.21.38 0.054
-
 benzyloxycarbonyl-Lys-Arg-SCH2CH(CH3)2
-
 Homo sapiens
3.4.21.38 0.054
-
 benzyloxycarbonyl-Thr-Arg-SCH2CH(CH3)2
-
 Homo sapiens
3.4.21.38 0.056
-
 benzyloxycarbonyl-Ser-Arg-SCH2CH(CH3)2
-
 Homo sapiens
3.4.21.38 0.095
-
 tert-butyloxycarbonyl-Arg-SCH2CH(CH3)2
-
 Homo sapiens
3.4.21.38 0.103
-
 benzyloxycarbonyl-Arg-SCH2CH(CH3)2
-
 Homo sapiens
3.4.21.38 0.15
-
 benzyloxycarbonyl-Glu-Arg-SCH2CH(CH3)2
-
 Homo sapiens
3.4.21.38 0.16
-
 benzyloxycarbonyl-Lys-Phe-Arg-4-nitroanilide
-
 Homo sapiens
3.4.21.38 0.18
-
 tert-butyloxycarbonyl-Arg-SCH2C6H5
-
 Homo sapiens
3.4.21.38 0.66
-
 benzyloxycarbonyl-Asn-Phe-Arg-4-nitroanilide
-
 Homo sapiens
3.4.21.38 0.7
-
 benzyloxycarbonyl-Lys-Gly-Arg-4-nitroanilide
-
 Homo sapiens
3.4.21.38 0.96
-
 benzyloxycarbonyl-Ser-Phe-Arg-4-nitroanilide
-
 Homo sapiens
3.4.21.38 1.5
-
 benzyloxycarbonyl-Ala-Phe-Arg-4-nitroanilide
-
 Homo sapiens
3.4.21.38 2.7
-
 benzyloxycarbonyl-Asn-Gly-Arg-4-nitroanilide
-
 Homo sapiens
3.4.21.38 3.9
-
 benzyloxycarbonyl-Ala-Gly-Arg-4-nitroanilide
-
 Homo sapiens
3.4.21.38 6.7
-
 benzyloxycarbonyl-Pro-Gly-Arg-4-nitroanilide
-
 Homo sapiens
3.4.21.38 8.2
-
 benzyloxycarbonyl-Phe-Gly-Arg-4-nitroanilide
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.38 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.38 benzyloxycarbonyl-Ala-Arg-SCH2C6H5 + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.38 benzyloxycarbonyl-Ala-Arg-SCH2CH(CH3)2 + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.38 benzyloxycarbonyl-Ala-Gly-Arg-4-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.38 benzyloxycarbonyl-Ala-Phe-Arg-4-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.38 benzyloxycarbonyl-Arg-SCH2CH(CH3)2 + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.38 benzyloxycarbonyl-Asn-Gly-Arg-4-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.38 benzyloxycarbonyl-Asn-Phe-Arg-4-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.38 benzyloxycarbonyl-Glu-Arg-SCH2CH(CH3)2 + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.38 benzyloxycarbonyl-Glu-Phe-Arg-4-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.38 benzyloxycarbonyl-Gly-Arg-SCH2CH(CH3)2 + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.38 benzyloxycarbonyl-Lys-Arg-SCH2CH(CH3)2 + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.38 benzyloxycarbonyl-Lys-Gly-Arg-4-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.38 benzyloxycarbonyl-Lys-Phe-Arg-4-nitroanilide + H2O best substrate Homo sapiens ?
-
 ?
3.4.21.38 benzyloxycarbonyl-Met-Arg-SCH2CH(CH3)2 + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.38 benzyloxycarbonyl-Phe-Arg-SCH2CH(CH3)2 + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.38 benzyloxycarbonyl-Phe-Gly-Arg-4-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.38 benzyloxycarbonyl-Phe-Phe-Arg-4-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.38 benzyloxycarbonyl-Pro-Arg-SCH2CH(CH3)2 + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.38 benzyloxycarbonyl-Pro-Gly-Arg-4-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.38 benzyloxycarbonyl-Pro-Phe-Arg-4-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.38 benzyloxycarbonyl-Ser-Arg-SCH2CH(CH3)2 + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.38 benzyloxycarbonyl-Ser-Gly-Arg-4-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.38 benzyloxycarbonyl-Ser-Phe-Arg-4-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.38 benzyloxycarbonyl-Thr-Arg-SCH2CH(CH3)2 + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.38 benzyloxycarbonyl-Val-Arg-SCH2CH(CH3)2 + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.38 tert-butyloxycarbonyl-Arg-SCH2C6H5 + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.38 tert-butyloxycarbonyl-Arg-SCH2CH(CH3)2 + H2O
-
 Homo sapiens ?
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.4.21.38 2.5
-
 benzyloxycarbonyl-Met-Arg-SCH2CH(CH3)2
-
 Homo sapiens
3.4.21.38 2.9
-
 tert-butyloxycarbonyl-Arg-SCH2C6H5
-
 Homo sapiens
3.4.21.38 8.3
-
 benzyloxycarbonyl-Phe-Arg-SCH2CH(CH3)2
-
 Homo sapiens
3.4.21.38 8.3
-
 benzyloxycarbonyl-Pro-Arg-SCH2CH(CH3)2
-
 Homo sapiens
3.4.21.38 9.2
-
 benzyloxycarbonyl-Glu-Arg-SCH2CH(CH3)2
-
 Homo sapiens
3.4.21.38 9.2
-
 benzyloxycarbonyl-Pro-Gly-Arg-4-nitroanilide
-
 Homo sapiens
3.4.21.38 9.2
-
 tert-butyloxycarbonyl-Arg-SCH2CH(CH3)2
-
 Homo sapiens
3.4.21.38 11
-
 benzyloxycarbonyl-Thr-Arg-SCH2CH(CH3)2
-
 Homo sapiens
3.4.21.38 13
-
 benzyloxycarbonyl-Ser-Arg-SCH2CH(CH3)2
-
 Homo sapiens
3.4.21.38 14
-
 benzyloxycarbonyl-Ala-Arg-SCH2CH(CH3)2
-
 Homo sapiens
3.4.21.38 14
-
 benzyloxycarbonyl-Phe-Gly-Arg-4-nitroanilide
-
 Homo sapiens
3.4.21.38 15
-
 benzyloxycarbonyl-Ala-Arg-SCH2C6H5
-
 Homo sapiens
3.4.21.38 15
-
 benzyloxycarbonyl-Lys-Arg-SCH2CH(CH3)2
-
 Homo sapiens
3.4.21.38 17
-
 benzyloxycarbonyl-Val-Arg-SCH2CH(CH3)2
-
 Homo sapiens
3.4.21.38 18
-
 benzyloxycarbonyl-Asn-Gly-Arg-4-nitroanilide
-
 Homo sapiens
3.4.21.38 22
-
 benzyloxycarbonyl-Arg-SCH2CH(CH3)2
-
 Homo sapiens
3.4.21.38 23
-
 benzyloxycarbonyl-Asn-Gly-Arg-4-nitroanilide
-
 Homo sapiens
3.4.21.38 23
-
 benzyloxycarbonyl-Asn-Phe-Arg-4-nitroanilide
-
 Homo sapiens
3.4.21.38 23
-
 benzyloxycarbonyl-Lys-Phe-Arg-4-nitroanilide
-
 Homo sapiens
3.4.21.38 25
-
 benzyloxycarbonyl-Lys-Gly-Arg-4-nitroanilide
-
 Homo sapiens
3.4.21.38 28
-
 benzyloxycarbonyl-Ser-Phe-Arg-4-nitroanilide
-
 Homo sapiens
3.4.21.38 34.6
-
 benzyloxycarbonyl-Ala-Phe-Arg-4-nitroanilide
-
 Homo sapiens
3.4.21.38 43
-
 benzyloxycarbonyl-Gly-Arg-SCH2CH(CH3)2
-
 Homo sapiens